Monday, November 2, 2015

THE SPICE OF LIFE: Health Benefits of Cinnamon

Cinnamon has been used for thousands of years to add flavor and also for many medicinal and ceremonial purposes. It was used for embalming in Egypt, as a treatment for digestive ailments, and as a fragrance during funeral ceremonies in ancient Rome (1).
Now, scientific research is revealing that cinnamon also has health benefits. Most prominently, cinnamon consumption has been shown to improve symptoms in type 2 diabetes by improving insulin sensitivity and cholesterol levels. Cinnamon seems to mimic the effects of insulin, allowing the body to remove glucose from the bloodstream (4, 12). Cinnamon has also been shown to reduce levels of cholesterol in the blood, which can be dysregulated in diabetics among others (2). Cinnamon can also improve sugar balance in the brain, which helps to improve cognitive functions. Studies in animals show that cinnamon alone protects brain cells from the harmful effects of a high sugar diet, including high levels of sugars in the blood and reduced sugar utilization in brain cells (3).
Even in healthy individuals, drinking cinnamon tea after dinner can also reduce blood sugar levels at night, which can protect your metabolism, prevent metabolic disease, and promote weight loss (6, 7, 12). Additionally, this spice appears to reduce appetite, which is a great way to curb late-night snacking. The amounts of cinnamon required in these studies ranges from a few milligrams to 3 grams. There are various cinnamon extracts that can be easily dissolved in water, making it easy to take large amounts as a dietary supplement (5).
Other studies show that cinnamon can decrease stiffness in arteries (5), reduce inflammation (8), and act as an antioxidant (9). The exact amounts of cinnamon required for these health effects aren't yet known and further research is needed to determine the full effect of cinnamon compounds on the body (10, 11). Nevertheless, these studies show results that are promising for using cinnamon as a natural therapeutic product. 

References
1) Kawatra P., Rajagopalan R. “Cinnamon: Mystic powers of a minute ingredient.” Pharmacognosy Research. 2015;7(Suppl 1):S1-S6. doi:10.4103/0974-8490.157990.
2) Allen, Robert W., et al. “Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis.” The Annals of Family Medicine 11.5 (2013): 452-459.
3) Anderson, Richard A., et al. “Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes.” (2013): e83243.
4) Howard, Molly E., and Nicole D. White. "Potential Benefits of Cinnamon in Type 2 Diabetes." American Journal of Lifestyle Medicine 7.1 (2013): 23-26.
5) Markey, Oonagh, et al. "Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast." Cardiovascular diabetology 10.1 (2011): 78.
6) Medagama, Arjuna B. "The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials." Nutrition journal 14.1 (2015): 108.
7) Bernardo, Maria Alexandra, et al. "Effect of Cinnamon Tea on Postprandial Glucose Concentration." Journal of diabetes research 2015 (2015).
8) Hong, Joung-Woo, et al. "Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models." BMC complementary and alternative medicine 12.1 (2012): 237.
9) Mancini-Filho, J., et al. "Antioxidant activity of cinnamon (Cinnamomum Zeylanicum, Breyne) extracts." Bollettino chimico farmaceutico 137.11 (1998): 443-447.
10) Rafehi, H., K. Ververis, and T. C. Karagiannis. "Controversies surrounding the clinical potential of cinnamon for the management of diabetes." Diabetes, Obesity and Metabolism 14.6 (2012): 493-499.
11) Gruenwald, Joerg, Janine Freder, and Nicole Armbruester. "Cinnamon and health." Critical reviews in food science and nutrition 50.9 (2010): 822-834.
12) Jitomir, Jean, and Darryn S. Willoughby. "Cassia cinnamon for the attenuation of glucose intolerance and insulin resistance resulting from sleep loss." Journal of medicinal food 12.3 (2009): 467-472.

Tuesday, September 29, 2015

SOME LIKE IT HOT: Science of the Sauna


We all complain about the hot summer swelter, but spending time in the heat can actually be beneficial for your health! Recent studies show that regular sauna use boosts your immune response (1,5), promotes cardiovascular and musculoskeletal health (2, 3), and can even help treat psychological disorders such as depression (4). 
          Sauna bathing is a special form of heat exposure that involves spending a short period of time, about 20-60 minutes, in exceptionally high environmental temperatures (4). The sauna itself is a wood-paneled room that is heated to 70-100oC (158-212 oF).  Regular heat exposure at these temperatures, known as hyperthermic conditioning, can actually produce some of the same physical benefits as regular exercise and can even be used as a way to train your body to withstand the stress of everyday life. 
In the sauna you can achieve similar physiological responses you incur during exercise:
1. Sweating
2. Rapid breathing
3. Increased heart rate
4. Dilated blood vessels
At the same time, your core temperature is increased and your body responds to these changes by generating heat shock proteins. These proteins are made in response to physical stress in order to repair damaged proteins and to signal for enhanced cell growth and natural growth hormone release (5, 6). These protective proteins and increased blood flow allow injuries to heal faster, prevent future injury (8, 9, 10, 11), and even treat chronic pain (10). Other benefits include increased muscle hypertrophy, protein synthesis, and improved insulin sensitivity (12, 13). Keep in mind there are some risks of sauna use, such as dehydration and dizziness. You may want to check with your doctor if you have cardiovascular abnormalities since heat is form of physical stress (14). 
There are also documented benefits of sauna use for cardiovascular health, and may be used as a potential hypertension treatment (3, 4, 15).  If you have the chance to give the sauna a try, at the very least you could get a relaxing break out of it!

For more details on how hyperthermic conditioning can impact your physiology check out the science as seen by Dr. Rhonda Patrick at https://foundmyfitness.com/ .

References
1.     Turturici, G., Geraci, F., Candela, M. E., Giudice, G., Gonzalez, F., & Sconzo, G. (2008). Hsp70 localizes differently from chaperone Hsc70 in mouse mesoangioblasts under physiological growth conditions. Journal of molecular histology, 39(6), 571-578.
2.     Iguchi, M., Littmann, A. E., Chang, S.-H., Wester, L. A., Knipper, J. S., & Shields, R. K. (2012). Heat Stress and Cardiovascular, Hormonal, and Heat Shock Proteins in Humans. Journal of Athletic Training, 47(2), 184–190.
3.     Crinnion, W. J. (2011). Sauna as a valuable clinical tool for cardiovascular, autoimmune, toxicant-induced and other chronic health problems. Alternative medicine review: a journal of clinical therapeutic, 16(3), 215-225.
4.     Kukkonen-Harjula, K., & Kauppinen, K. (2006). Health effects and risks of sauna bathing. International journal of circumpolar health, 65(3).
5.     Schlesinger, M. J. (1990). Heat shock proteins. J Biol Chem, 265(21), 12111-12114.
6.     Hannuksela, M. L., & Ellahham, S. (2001). Benefits and risks of sauna bathing.The American journal of medicine, 110(2), 118-126.
7.     Selsby, J. T., Rother, S., Tsuda, S., Pracash, O., Quindry, J., & Dodd, S. L. (2007). Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading. Journal of Applied Physiology,102(4), 1702-1707.
8.     Scoon, G. S., Hopkins, W. G., Mayhew, S., & Cotter, J. D. (2007). Effect of post-exercise sauna bathing on the endurance performance of competitive male runners. Journal of Science and Medicine in Sport, 10(4), 259-262.
9.     Naito, H., Powers, S. K., Demirel, H. A., Sugiura, T., Dodd, S. L., & Aoki, J. (2000). Heat stress attenuates skeletal muscle atrophy in hindlimb-unweighted rats. Journal of Applied Physiology, 88(1), 359-363.
10.  Gore, J. Discover Saunas Super Healing Powers For Your Back Pain, Herniated Disc Or Sciatica. Obtained Sept. 23, 2015 from <http://strongerfitteryou.com/discover-saunas-super-healing-powers-pain-herniated-disc-sciatica/>
11.  Asea, A. A., Almasoud, N. N., Krishnan, S., & Kaur, P. (2015). Heat Shock Protein-Based Therapies. Heat Shock Proteins.
12.  Kokura, S., Adachi, S., Manabe, E., Mizushima, K., Hattori, T., Okuda, T., ... & Yoshikawa, T. (2007). Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice. International journal of hyperthermia, 23(3), 259-265.
13.  Carro, E., Trejo, J. L., Núñez, A., & Torres-Aleman, I. (2003). Brain repair and neuroprotection by serum insulin-like growth factor I. Molecular neurobiology,27(2), 153-162.
14.  Laukkanen, T., Khan, H., Zaccardi, F., & Laukkanen, J. A. (2015). Association between sauna bathing and fatal cardiovascular and all-cause mortality events.JAMA internal medicine, 175(4), 542-548.
15.  Vuori, I. (1987). Sauna bather's circulation. Annals of clinical research, 20(4), 249-256.